Graves' Orbitopathy
نویسندگان
چکیده
1Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan 2Department of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Penrith, NSW 2751, Australia 3Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany 4Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi 480-1195, Japan
منابع مشابه
CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease
Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775), CTLA-4g.*642AT(8_33), CT60(rs3087243), Jo31(rs11571302), ICOSc.1554+4GT(8_15...
متن کاملOptimal management of Graves orbitopathy: a multidisciplinary approach.
Graves' thyroid disease is a relatively common disorder in endocrinology and general internal medicine practice. Graves' hyperthyroidism is mediated by circulating stimulating autoantibodies. Up to 60% of patients with Graves' hyperthyroidism develop some form of Graves' orbitopathy. Immune reactivity to the thyroid-stimulating hormone receptor is also thought to play a role in the immunopathog...
متن کاملStatins and Thyroidectomy May Reduce the Risk of Orbitopathy Developing in Patients with Graves’ Disease
Background Graves’ orbitopathy (GO) is a component of Graves’ disease (GD) that is difficult to treat and may be very debilitating for the patient. Orbitopathy (ophthalmopathy [harder to pronounce]) is a significant problem for about 5% to 10% of patients with Graves’ disease. The factors that cause a predisposition to it are not clear. The current study examines a database of patients with Gra...
متن کاملUpper eyelid retraction disclosed after edrophonium chloride administration in a patient with Graves’ orbitopathy and myasthenia gravis
Patients with Graves' orbitopathy have a higher probability of myasthenia gravis than does the normal population. Overlapping clinical features cause diagnostic confusion in such a situation. We herein report a patient with Graves' orbitopathy and myasthenia gravis (GO-MG) with normal left eyelid height, but in whom upper eyelid retraction was shown after edrophonium chloride administration. Up...
متن کاملNot All Orbitopathy Is Graves’: Discussion of Cases and Review of Literature
INTRODUCTION Graves' orbitopathy is the extra thyroidal manifestation of Graves' disease and the most common cause of exophthalmos. It is also known as thyroid-associated orbitopathy (TAO) as it occasionally occurs in euthyroid or hypothyroid patients with chronic thyroiditis. 5% of patients with Graves' orbitopathy can be euthyroid or hypothyroid as they have low titers of anti-thyrotropin-rec...
متن کاملAssociation between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves' Disease Study
Background. Graves' disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel. Objectives. To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves' disease (hyperthyroidism, goiter, and presence of orbitopathy) at the time of diagnosis of hyperthyroidism. Methods. We des...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015